Blinded sample size recalculation in clinical trials with binary composite endpoints
نویسندگان
چکیده
منابع مشابه
Composite Endpoints in Clinical Trials
Composite endpoints are often used in clinical trials, especially in the cardiovascular area. Decreases in sample size requirements, ability to assess the net effect of an intervention and to avoid bias in presence of competing risks are the most cited advantages for their use. However, there is a risk of misinterpretation when heterogeneity among components with respect to either importance, n...
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ژورنال
عنوان ژورنال: Journal of Biopharmaceutical Statistics
سال: 2016
ISSN: 1054-3406,1520-5711
DOI: 10.1080/10543406.2016.1198371